Lemon twist catalysis

PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism.

FK506-binding protein (FKBP) catalyzes the cis-trans isomerization of the peptidyl-prolyl amide bond (the PPIase reaction) and is the major intracellular receptor for the immunosuppressive drugs FK506 and rapamycin. One mechanism proposed for catalysis of the PPIase reaction requires attack of an enzyme nucleophile on the carbonyl carbon of the isomerized peptide bond. An alternative mechanism ...

Squeezing LEMON with GATE

An increasing number of enterprises are beginning to include ontologies into Text Analytics (TA) applications. This can be challenging for a TA group wishing to avail of such technologies due to the manual effort needed to map language resources within a TA system for a new domain. Ontology lexicalization offers a solution to this problem by seeking to automatically generate lexical resources i...

Observations on Lemon Cells

Ontology Lexicalisation: The lemon Perspective

Ontologies (Guarino1998) capture knowledge but fail to capture the structure and use of terms in expressing and referring to this knowledge in natural language. The structure and use of terms is the concern of terminology as well as lexicology. In recent years, the relevance of terminology in knowledge representation has been recognized again (for example the advent of SKOS1) but less considera...

A lemon lexicon for DBpedia

As the body of knowledge available as linked data grows, so does the need to provide methods that make this knowledge accessible for humans. Such methods usually require knowledge about how the vocabulary elements used in the available ontologies and datasets are verbalized in natural language. This has lead to much interest in the development of models and frameworks for publishing ontology le...